Key result
Plasma atrial natriuretic peptide levels were elevated approximately twofold in full-term neonates at 3-4 days of age, returning to normal levels seen in older children and adults thereafter.
Why the study?
The pattern and levels of atrial natriuretic peptide in infants and children during postnatal adaptation were not well characterized.
Cross-Sectional (n=192)
Answers are grounded in this paper and cite their sources.
Plasma ANP levels are elevated during postnatal adaptation in neonates but normalize to adult levels by 4 months of age.
Atrial natriuretic peptide (ANP) was measured in the plasma of 192 normal infants and children aged 1 day to 18 years. Plasma ANP was high during postnatal adaptation, particularly in premature infants. In 96 infants and children aged 4 months to 18 years, plasma ANP was similar to values obtained in 7 healthy adult volunteers (23.9 +/- 11.9 vs. 25.7 +/- 4.6 fmol/ml). There was no significant relationship between ANP and age. ANP is elevated about twofold in full-term neonates being 3-4 days of age, and returned to normal thereafter. It is concluded that ANP is raised during the postnatal adaptation. This hormone is possibly involved in the postnatal volume contraction and may antagonize vasoconstrictor hormones that are elevated during the postnatal period.
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Rascher et al. (2008) conducted a cross-sectional in Healthy (n=192). Postnatal period vs. Older children and adults was evaluated on Plasma atrial natriuretic peptide (ANP) levels. Plasma atrial natriuretic peptide levels were elevated approximately twofold in full-term neonates at 3-4 days of age, returning to normal levels seen in older children and adults thereafter.
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