Why the study?
What is the relationship between plasma levels of Nt-proANP, renal function, age, and heart failure in children?
What is the relationship between plasma levels of Nt-proANP, renal function, age, and heart failure in children?
In children, plasma levels of Nt-proANP are age-dependent and moderately elevated in severe renal impairment, but the excessive elevation caused by heart failure greatly exceeds the influence of renal dysfunction.
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Nt-proANP interpretation in children with HF requires age and GFR adjustment; leaves open its added diagnostic or prognostic utility.
Holmström et al. (2000) studied this question.
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