Key result
Plasma NT-proBNP peaks in neonates and declines steadily with age regardless of sex.
Why the study?
Reference data for plasma NT-proBNP concentrations in infants and children are rare, limiting diagnostic utility in pediatric cardiology.
Cross-Sectional (n=91)
Effect estimate: r = -0.523
p-value: p=<0.0001
Plasma NT-proBNP concentrations are highest in neonates and decrease with age throughout childhood, highlighting the critical need for age-matched reference values when evaluating pediatric patients.
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Provides age-specific NT-proBNP reference values in children; leaves open diagnostic performance in congenital heart disease.
Rauh et al. (2003) conducted a cross-sectional in Healthy control population (n=91). Age was evaluated on Plasma NT-proBNP concentration (r = -0.523, p=<0.0001). Plasma NT-proBNP concentrations were highest in neonates and decreased significantly with age in children >1 month (r = -0.45; P<0.001), with no significant difference between sexes.
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