Key result
Plasma BNP concentrations peaked at 0 days of age (56.7 fmol/ml), 21 times higher than in the umbilical vein (2.7 fmol/ml), and decreased to adult levels by 3 months of age.
Cross-Sectional (n=78)
Absolute Event Rate: 56.7% vs 2.7%
Plasma BNP concentrations peak immediately after birth and normalize to adult levels by 3 months of age, establishing normal pediatric reference ranges and suggesting a distinct physiological role in perinatal circulatory changes.
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Neonates require age-specific BNP reference ranges; extends pediatric norms while leaving open perinatal physiology roles.
Yoshibayashi et al. (1995) conducted a cross-sectional in Healthy (n=78). Age (0 days of age) vs. Umbilical vein was evaluated on Plasma BNP concentration (fmol/ml). Plasma BNP concentrations peaked at 0 days of age (56.7 fmol/ml), 21 times higher than in the umbilical vein (2.7 fmol/ml), and decreased to adult levels by 3 months of age.
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