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September 27, 2018Aging Clinical and Experimental ResearchOpen Access

In patients aged 80 or older receiving a permanent pacemaker, an eGFR < 30 ml/min/1.73 m2 strongly predicted worse long-term survival (HR 4.07), as did low BMI, dyspnea, and longer hospital stay.

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Population

100 patients aged ≥ 80 years who met indications for chronic cardiac pacing and received permanent pacemaker…

Design

Cohort

Follow-up

4.0 ± 2.7 years

Key result

In patients aged 80 or older receiving a permanent pacemaker, an eGFR < 30 ml/min/1.73 m2 strongly predicted worse long-term survival (HR 4.07), as did low BMI, dyspnea, and longer hospital stay.

Authors

CCChi‐Wen ChengCWChao‐Hung WangWCWei-Siang Chen

Discussion

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Overview

eGFR <30, low BMI, dyspnea, and prolonged stay identify high-risk octogenarians post-pacemaker; hypothesis-generating for geriatric risk stratification.

Study Design

Type

Cohort (n=100)

Multicenter

No

Structured PICO

P
Population
100 patients aged 80 years or older who received permanent pacemaker implantation, followed for a mean of 4.0 years.
E
Exposure
Permanent pacemaker (PPM) implantation (80% dual-chamber, 20% single-chamber)
O
Outcome
All-cause mortalityhard clinical

Main Result

Hazard Ratio: 4.07 (95% CI 1.95–8.52)

p-value: p=<0.001

In octogenarians undergoing permanent pacemaker implantation, longer pre-procedure hospital stay, eGFR < 30, BMI < 21, and dyspnea are independent predictors of worse long-term survival, highlighting the need for comprehensive geriatric assessment in these high-risk patients.

Limitations

  • Single hospital retrospective study with potential selection bias
  • Relatively small sample size
  • Lack of psychosocial and functional assessments
  • Did not assess quality of life
  • Did not include psychosocial and functional assessments
  • Did not evaluate quality of life

Cite This Study

Cheng et al. (2018) conducted a cohort in Patients aged 80 or older requiring permanent pacemaker implantation (n=100). eGFR < 30 ml/min/1.73 m2 vs. eGFR > 60 ml/min/1.73 m2 was evaluated on All-cause mortality (HR 4.07, 95% CI 1.95-8.52, p=<0.001). In patients aged 80 or older receiving a permanent pacemaker, an eGFR < 30 ml/min/1.73 m2 strongly predicted worse long-term survival (HR 4.07), as did low BMI, dyspnea, and longer hospital stay.

synapsesocial.com/papers/6a96f11b96bab72bf50e4c82https://doi.org/10.1007/s40520-018-1044-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Survival predictors after pacemaker implantation in a very elderly population2024
  2. 2Short- and long-term survival in patients over 90 years old undergoing pacemaker implantation2023 · 2 citations
  3. 3Mortality and prognostic factors in pacemaker implantation in the extreme eldery2025
  4. 4Survival and Functional Independence after Implantation of a Permanent Pacemaker in Octogenarians and Nonagenarians: A Population-Based Study1996 · 51 citations
  5. 5Procedural safety and long‐term follow‐up after pacemaker implantation in nonagenarians2018 · 5 citations