Key result
Fruitflow® inhibited doxorubicin-induced cardiotoxicity in cardiomyoblasts and high-fat diet-induced dysfunction in rats by reducing oxidative stress and inflammation.
Why the study?
Natural compounds offer promising targets for cardioprotection, motivating the evaluation of Fruitflow, a water-soluble tomato extract, against doxorubicin-induced toxicity and high-fat diet-induced pathological cardiac alterations.
Does Fruitflow® prevent doxorubicin-induced toxicity and high-fat diet-induced cardiac dysfunction in rat models?
Does Fruitflow® prevent doxorubicin-induced toxicity and high-fat diet-induced cardiac dysfunction in rat models?
Answers are grounded in this paper and cite their sources.
Fruitflow® demonstrates cardioprotective effects against doxorubicin-induced cardiotoxicity in vitro and high-fat diet-induced cardiac dysfunction in vivo, suggesting potential as a therapeutic agent.
Natural compounds offer promising targets for cardioprotection, which could lead to enhanced clinical outcomes. We aimed to determine the cardioprotective effects of Fruitflow®, a water-soluble tomato extract known for its anti-platelet effects in doxorubicin-induced toxicity in rat cardiomyoblast cell line pathological alteration in heart tissue of high fat-fed Wistar Albino rats. The cardioprotective effect of Fruitflow® was investigated using H9c2 (2−1) cells (rat cardiomyoblast cell line) and high-fat diet-fed Wistar Albino rats. We evaluated morphological changes, cell proliferation, cell migration, antioxidant activity, cell cycle progression, and mitochondrial membrane potential after the Fruitflow® treatment in the Doxorubicin-injured H9c2 (2−1) cell line. We studied lipid profiles, inflammation, oxidative stress, and cardiac function regulatory enzyme activity in the rat model. Fruitflow® dose-dependently stimulated cell proliferation and migration in Doxorubicin-injured H9c2 (2−1) cells, potentially promoting cardiac regeneration and supporting tissue repair. Fruitflow® modulated the cell cycle, improved mitochondrial function, and reduced oxidative stress. Furthermore, it significantly improved lipid profiles and enzyme activities and reduced inflammation and oxidative stress in high-fat-fed rats. Fruitflow® also modulated the expression of genes involved in cardiac remodeling, mitochondrial biogenesis, inflammation, and vascular function. Our findings suggest Fruitflow® may have cardioprotective effects, making it a potential treatment option for cardiac ailments. Larger-scale clinical trials were recommended further to determine the efficacy and safety of Fruitflow® as a potential therapeutic agent for cardiac diseases, potentially in combination with other cardioprotective medications. Fruitflow® inhibits doxorubicin-induced cardiotoxicity in cardiomyoblasts and high-fat diet-induced dysfunction in rats. Created in BioRender. Duttaroy, A. (2024) BioRender.com/m12l525 • Fruitflow promotes cardiomyoblast proliferation, cycle progression, and migration in doxorubicin-induced H9c2 (2−1) cells. • Fruitflow reduces the Oxidative Stress and inflammation on H9c2 (2−1) cells and high-fat diet-fed Wistar albino rats. • Fruitflow positively regulates key cardiac gene expression, promoting cardiac remodeling and fibrosis-like phenotype.
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Das et al. (2024) studied Doxorubicin-induced cardiotoxicity and high-fat diet-induced dyslipidemia. Fruitflow® was evaluated on Cardioprotective effects (cell proliferation, migration, oxidative stress, inflammation, and lipid profiles). Fruitflow® inhibited doxorubicin-induced cardiotoxicity in cardiomyoblasts and high-fat diet-induced dysfunction in rats by reducing oxidative stress and inflammation.
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