Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 6, 2023International Journal of Molecular SciencesOpen Access

Flavonoids from Hippophae rhamnoides Linn. Revert Doxorubicin-Induced Cardiotoxicity through Inhibition of Mitochondrial Dysfunction in H9c2 Cardiomyoblasts In Vitro

View Full Paper
Ask AI
Bookmark
Share

Key result

Pretreatment with flavonoids from Hippophae rhamnoides Linn. significantly relieved Dox-induced cardiac injury and inhibited cardiomyocyte apoptosis via the 'JNK-Sab-Ros' signal pathway.

Why the study?

Treatment with the anti-cancer drug doxorubicin is limited by cumulative cardiotoxicity.

Do flavonoids from Hippophae rhamnoides Linn. prevent doxorubicin-induced cardiotoxicity in H9c2 cardiomyoblasts?

Population

H9c2 cardiomyoblasts in vitro

Comparison

Three flavonoids from seabuckthorn seed residue vs doxorubicin alone

Design

In vitro preclinical laboratory study

Authors

WZWenna ZhouJOJian OuyangNHNa Hu

Discussion

Loading...

Member takes

Overview

Requires validation in animal models; leaves open any clinical role in doxorubicin cardiotoxicity prevention.

Structured PICO

Do flavonoids from Hippophae rhamnoides Linn. prevent doxorubicin-induced cardiotoxicity in H9c2 cardiomyoblasts?

P
Population
In vitro study using H9c2 cardiomyoblasts to investigate the protective effect of three flavonoids against Doxorubicin-induced cardiotoxicity.
I
Intervention
Pretreatment with three flavonoids (3-O-β-d-Sophorosylkaempferol-7-O-{3-O-[2(E)-2,6-dimethyl-6-hydroxyocta-2,7-dienoyl]}-α-L-rhamnoside, kaempferol 3-sophoroside 7-rhamnoside, and hippophanone) from Hippophae rhamnoides Linn.
C
Comparator
Doxorubicin treatment without flavonoid pretreatment
O
Outcome
Dox-induced H9c2 cell apoptosis and cardiac injurysurrogate

Flavonoids from Hippophae rhamnoides Linn. protect against doxorubicin-induced cardiotoxicity in vitro via the JNK-Sab-ROS signaling pathway.

Cite This Study

Zhou et al. (2023) studied Doxorubicin-induced cardiotoxicity. Flavonoids from Hippophae rhamnoides Linn. (F-A, F-B, F-C) vs. Doxorubicin alone was evaluated on Dox-induced H9c2 cell apoptosis and cardiac injury. Pretreatment with flavonoids from Hippophae rhamnoides Linn. significantly relieved Dox-induced cardiac injury and inhibited cardiomyocyte apoptosis via the 'JNK-Sab-Ros' signal pathway.

synapsesocial.com/papers/6a7a4dcb5968508e56f3bc03https://doi.org/10.3390/ijms24043174
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1DiOHF Protects Against Doxorubicin-Induced Cardiotoxicity Through ERK1 Signaling Pathway2019 · 27 citations
  2. 2Cardioprotective effects of the flavonoid quercetin against doxorubicin-Induced cardiotoxicity in H9c2 cardiomyoblasts2025 · 1 citations
  3. 3Kaempferol protects against doxorubicin-induced myocardial damage by inhibiting mitochondrial ROS-dependent ferroptosis2025 · 35 citations
  4. 4Myricetin Prevents Doxorubicin-Induced Oxidative Stress and Mitochondrial Apoptotic Pathway in H9C2 Cardiac Cells2025
  5. 5Doxorubicin-Induced Cardiomyopathy: A Preliminary Study on the Cardioprotective Benefits of 7-Hydroxyflavanone2023 · 6 citations