Key result
Ganglionic blockade with hexamethonium bromide significantly decreased hindquarter peripheral resistance in four models of hypertensive rats, but not in normotensive controls, indicating abnormal vasoconstrictor tone.
Why the study?
Does ganglionic blockade with hexamethonium bromide reveal abnormal hindquarter vasoconstrictor tone in various experimental models of hypertensive rats compared to normotensive controls?
Does ganglionic blockade with hexamethonium bromide reveal abnormal hindquarter vasoconstrictor tone in various experimental models of hypertensive rats compared to normotensive controls?
Abnormal hindquarter vasoconstrictor tone is a common pathophysiological feature across multiple experimental rat models of hypertension.
Supports common abnormal vasoconstrictor tone across hypertensive rat models; leaves open translation to human hypertension.
Hindquarter peripheral resistance, calculated as arterial pressure divided by hindquarter blood flow, decreased significantly on ganglionic blockade with hexamethonium bromide in four kinds of experimentally hypertensive rats, i.e. spontaneously hypertensive rats (SHR), DOCA-salt hypertensive rats, and one-kidney, one-clip and two-kidney, one-clip renovascular hypertensive rats, but not in normotensive control rats in the conscious state. Abnormal hindquarter vasoconstrictor tone seems to be a feature common to various kinds of hypertensive rats.
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Juro Iriuchijima (1988) studied Hypertension (n=44). Hexamethonium bromide vs. Normotensive control rats was evaluated on Percent change in hindquarter resistance on ganglionic blockade. Ganglionic blockade with hexamethonium bromide significantly decreased hindquarter peripheral resistance in four models of hypertensive rats, but not in normotensive controls, indicating abnormal vasoconstrictor tone.
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