Key result
A 14.5K protein isolated from Borna disease virus-infected brains and tissue cultures was found to be infection-specific, resistant to proteinase K, and likely an internal virion component.
Identified a 14.5K infection-specific protein from Borna disease virus-infected tissues, likely an internal virion component.
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Provides a potential Borna disease virus marker in animal models; leaves open diagnostic or pathogenic roles in humans.
A protein with an apparent molecular weight of 14500 (14.5K) was extractable from homogenates of Borna disease virus-infected brains and tissue cultures using high concentrations of detergent and salt and by differential centrifugation procedures. The protein, present in an aggregated form, was remarkably resistant to proteinase K. Specific antibodies prepared in the homologous system (rat) recognized the 14.5K protein from various sources (infected brain of rat, mouse or chicken, and tissue cultures), but did not neutralize infectivity nor stain Borna disease virus-specific antigens from in vitro or in vivo preparations. Post-infection immune sera from different animal species did not detect the protein. This 14.5K protein was infection-specific but not disease-specific, and is inferred to be part of an internal virion component.
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Schädler et al. (1985) studied Borna disease virus infection. Isolation of 14.5K protein was evaluated on Protein characterization. A 14.5K protein isolated from Borna disease virus-infected brains and tissue cultures was found to be infection-specific, resistant to proteinase K, and likely an internal virion component.
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