Genetic polymorphism of DNATyper X19 kit in Northern Chinese Han people

This is the authors' abstract. We don't add key points for this paper.

Objective. To evaluate the value of DNATyper X19 kit in the forensic application. Methods. In this study, we carried out a survey of genetic polymorphism from 374 Northern Chinese Han individuals. Results. A total of 140 alleles were detected among the 18 X-STR loci from 374 Northern Chinese Han individuals, 228 haplotypes were detected from the 228 males, the diversity is 100%. No markers departed from Hardy-Weinberg equilibrium after applying Bonferroni's correction for multiple testing (p=0.05/18), GATA31E08-DXS6797, DXS8377-DXS10079 were in linkage disequilibrium (LD) in this study (p=0.05/153). The polymorphism information content (PIC) was 0.434-0.908 and the discrimination power (DP) was 0.432-0.983. The combined discrimination power was 0.99999993 for male and 0.999999992 for female. The combined mean exclusion chance was 0.999993 in duo cases (CMECduo) and 0.999999994 in trio case (CMECtrio). Conclusions. DNATyper X19 kit showed potential value for complicated paternity cases.