Key result
Diminished endothelial NOS expression and NO availability in the paraventricular nucleus of heart failure rats resulted in blunted NO inhibitory actions on neuronal activity and sympathoexcitatory outflow.
Population
Sham and heart failure (HF) rats
Comparison
Assessment of endothelial NOS isoform… vs Sham rats
Design
Preclinical
Authors
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May underlie neurohumoral activation in HF; hypothesis-generating from animal data and should not yet change practice.
The study identifies blunted central nervous system endothelial NOS-derived NO as a pathophysiological mechanism underlying neurohumoral activation in heart failure.
Biancardi et al. (2011) studied Heart failure (animal model). Heart failure vs. Sham was evaluated on Expression, cellular distribution, and functional relevance of the endothelial NOS isoform within the hypothalamic paraventricular nucleus. Diminished endothelial NOS expression and NO availability in the paraventricular nucleus of heart failure rats resulted in blunted NO inhibitory actions on neuronal activity and sympathoexcitatory outflow.