Key result
Epidemiological investigation identified 29 pestivirus strains (24 Pestivirus A and 5 Pestivirus H) in cattle with respiratory infections from backyard farms in Central China, revealing extensive genetic variations.
Why the study?
The study was conducted to investigate pestiviruses circulating in backyard cattle farms in central China.
Cross-Sectional (n=83)
This study reveals extensive genetic diversity of bovine pestiviruses, including the first molecular evidence of natural Pestivirus H infections in cattle in China, which is important for developing diagnostic methods and vaccines.
Answers are grounded in this paper and cite their sources.
May inform pestivirus surveillance in Chinese cattle; leaves open diagnostic and vaccine implications pending prospective validation.
Bovine pestiviruses include Pestivirus A (BVDV-1), Pestivirus B (BVDV-2), and Pestivirus H, which was originally called HoBi-like pestivirus. We conducted an epidemiological investigation for pestiviruses circulating in backyard cattle farms in central China. RT-PCR assays and sequences analysis were conducted on 54 nasal swabs, 26 serum samples, and three lung samples from cattle with respiratory infections and identified 29 pestivirus strains, including 24 Pestivirus A and five Pestivirus H strains. Phylogenetic analysis based on partial 5’-UTR and Npro sequences showed that the genotypes of 24 Pestivirus A strains included Pestivirus A 1b (6 isolates), Pestivirus A 1m (6 isolates), Pestivirus A 1q (2 isolates), Pestivirus A 1u (1 isolates), and Pestivirus A 1o (9 isolates, a putative new sub-genotype). In addition, a single “Pestivirus H a” genotype included all five Pestivirus H strains. This study revealed extensive genetic variations within bovine pestivirus isolates derived from cattle in backyard farms in Central China, and this epidemiological information improves our understanding of the epidemics of bovine Pestiviruses, as well as will be useful in designing and evaluating diagnostic methods and developing more effective vaccines.
No takes yet. Share an insight, caveat, or question.
Shi et al. (2020) conducted a cross-sectional in Respiratory infections in cattle (n=83). Bovine pestivirus infection was evaluated on Detection and genetic diversity of bovine pestiviruses. Epidemiological investigation identified 29 pestivirus strains (24 Pestivirus A and 5 Pestivirus H) in cattle with respiratory infections from backyard farms in Central China, revealing extensive genetic variations.
Synapse has enriched 10 related papers. Consider them for comparative context: