A framework for ongoing curation and expansion of PRRSV-2 lineage nomenclature

Porcine reproductive and respiratory syndrome virus-type 2 (PRRSV-2) is a rapidly evolving RNA virus with major impacts on global swine production. To support epidemiological surveillance and characterization of viral diversity, a phylogenetic lineages and sub-lineages classification system has been developed for PRRSV-2. However, continued viral evolution and expanding molecular surveillance highlight the need for a coordinated global framework to maintain and update nomenclature. To address this need, the International PRRSV-2 Nomenclature Consortium (IPNC) was established to curate PRRSV-2 lineages nomenclature and promote standardized classification practices. Here, we summarize the PRRSV-2 lineages classification system, describe available sequence classification webtools, and outline procedures for proposing and endorsing new lineages and sub-lineages. The IPNC framework is intended to improve consistency and enhance communication among researchers and practitioners worldwide.