Key result
In the rat isolated mesenteric artery, contractile responses are elicited by P2Y6 and P2Y2/P2Y4 receptors, while relaxation is mediated by P2Y1 and P2Y2/P2Y4 receptors.
Population
Rat isolated mesenteric artery
Design
Preclinical
Authors
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Rat mesenteric artery data on P2Y-mediated tone do not inform practice; leaves open subtype-selective targeting for future vascular studies.
UDPbetaS and UTPgammaS are useful pharmacological tools for discriminating between P2 receptor subtypes mediating vascular contraction and relaxation.
Malmsjö et al. (2000) studied Rat isolated mesenteric artery. Extracellular nucleotides (UDPbetaS, UTPgammaS) was evaluated on Contractile and relaxant effects. In the rat isolated mesenteric artery, contractile responses are elicited by P2Y6 and P2Y2/P2Y4 receptors, while relaxation is mediated by P2Y1 and P2Y2/P2Y4 receptors.
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