Why the study?
Does prolonged infusion of human α-CGRP alter regional hemodynamics in conscious Long Evans rats?
Population
Conscious, Long Evans rats chronically instrumented for the assessment of changes in regional blood flows
Comparison
Human α-calcitonin gene-related peptide infused… vs Vehicle infusion for 3 days
Design
Preclinical
Follow-up
4 days
Authors
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Rapid desensitization to α-CGRP in rats cautions against assuming sustained effects; leaves open clinical translation and dose-escalation strategies.
Does prolonged infusion of human α-CGRP alter regional hemodynamics in conscious Long Evans rats?
Prolonged infusion of human α-CGRP in rats causes initial hemodynamic changes followed by desensitization, which can be overcome by dose escalation.
Gardiner et al. (1991) studied this question.
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