Population
Conscious, chronically-instrumented, Long Evans rats
Comparison
Human alpha-calcitonin gene-related peptide… vs Endothelin-1 or L-NAME alone
Design
Preclinical
Authors
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CGRP effects in rat vasoconstriction models are hypothesis-generating; leaves open any clinical role in human hypertension or endothelial dysfunction.
Human alpha-CGRP counteracts specific regional vasoconstrictor effects of endothelin-1 and L-NAME in conscious rats, with some effects modulated by the renin-angiotensin system and nitric oxide.
Gardiner et al. (1991) studied this question.
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