Key result
Managed Ventricular Pacing significantly reduced right ventricular pacing compared to Search AV+ at 12 months in patients with SND (0.20% vs 1.4%, P<0.0001) and AVB (11.8% vs 98.1%, P<0.001).
Why the study?
Does the Managed Ventricular Pacing (MVP) algorithm reduce the percentage of right ventricular pacing compared to the Search AV+ (SAV+) algorithm in patients with dual-chamber pacemakers?
RCT (n=385)
1:1
Yes
Does the Managed Ventricular Pacing (MVP) algorithm reduce the percentage of right ventricular pacing compared to the Search AV+ (SAV+) algorithm in patients with dual-chamber pacemakers?
The Managed Ventricular Pacing (MVP) algorithm significantly reduces unnecessary right ventricular pacing compared to the Search AV+ (SAV+) algorithm in patients with dual-chamber pacemakers over 12 months.
Answers are grounded in this paper and cite their sources.
MVP should be prioritized over SAV+ to minimize RV pacing in dual-chamber pacemakers; confirms superiority for pacing reduction in SND and AVB.
AIMS: The present study was to assess the reduction of right ventricular pacing (RVP) by pacemaker algorithms of Managed Ventricular Pacing (MVP) and Search AV+ (SAV+) interval over a period of 12 months. METHODS AND RESULTS: A total of 385 patients indicated for a dual-chamber pacemaker (DC-PM) were enrolled in the prospective, randomized COMPARE study at 29 centres in China between June 2009 and April 2011. Patients implanted with DC-PMs were randomized in a 1 : 1 ratio to the MVP group or the SAV+ group. The percentage of VP (%VP) was obtained from the device diagnostic data at 1-, 6-, and 12-month follow-ups and was expressed as the median %VP over all beats in patients with sinus node dysfunction (SND) and atrioventricular block (AVB) excluding persistent third-degree AVB. Of 385 enrolled patients, 253 had SND and 72 had AVB. The %VP in the MVP group was significantly lower than that in the SAV+ group at 1-, 6-, and 12-month follow-ups, respectively. At 12-month follow-up, the median %VP in SND patients was 0.20% in the MVP group and 1.4% in the SAV+ group (P < 0.0001) and the median %VP in AVB patients was 11.8% in the MVP group and 98.1% in the SAV+ group (P < 0.001). There was no statistical difference in %VP from 1- to 12-month follow-up. A trend in the correlation between %VP and AT/AF burden was observed. CONCLUSION: Over 12-month follow-up, the %VP was lower for MVP than SAV+ in patients with either SND or AVB. The sustainable %VP reduction has potential implications in reducing the development of heart failure and/or atrial arrhythmia morbidity.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2014) conducted an RCT in Sinus node dysfunction and atrioventricular block (n=385). Managed Ventricular Pacing (MVP) vs. Search AV+ (SAV+) was evaluated on Percentage of right ventricular pacing (%VP). Managed Ventricular Pacing significantly reduced right ventricular pacing compared to Search AV+ at 12 months in patients with SND (0.20% vs 1.4%, P<0.0001) and AVB (11.8% vs 98.1%, P<0.001).
Synapse has enriched 10 related papers. Consider them for comparative context: