Key result
Higher polygenic scores for BMI and waist circumference were associated with higher adiposity, with behavioral factors mediating 6.6% and 9.6% of these associations, respectively.
Why the study?
It was unknown whether physical activity, personality, cognition, education, and depressive symptoms mediate the association between polygenic scores for BMI and waist circumference and phenotypic adiposity.
Do physical activity, personality, cognition, education, and depressive symptoms mediate the association between polygenic scores for BMI and waist circumference and phenotypic adiposity?
Population
9,139 genotyped individuals aged 50 to 107 years from the Health and Retirement Study
Comparison
Polygenic scores for BMI and waist circumference and candidate mediators
Design
Observational cohort study
Authors
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Behavioral mediation of genetic adiposity risk is hypothesis-generating; leaves open causal effects and should not yet change practice.
Observational (n=9,139)
Do physical activity, personality, cognition, education, and depressive symptoms mediate the association between polygenic scores for BMI and waist circumference and phenotypic adiposity?
Genetic predisposition to obesity may lead to higher adiposity in adulthood partly through less adaptive behavioral, personality, and educational profiles.
Stéphan et al. (2020) conducted an observational in Phenotypic adiposity (n=9,139). Polygenic scores for BMI and waist circumference was evaluated on BMI and waist circumference. Higher polygenic scores for BMI and waist circumference were associated with higher adiposity, with behavioral factors mediating 6.6% and 9.6% of these associations, respectively.
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