The Influence of Gonadal Hormones on Serum Lipids and Lipoproteins: Studies in Normal and Hypogonadal Subjects

Article1 November 1957THE INFLUENCE OF GONADAL HORMONES ON SERUM LIPIDS AND LIPOPROTEINS: STUDIES IN NORMAL AND HYPOGONADAL SUBJECTSROBERT H. FURMAN, M.D., F.A.C.P., R. PALMER HOWARD, M.D., F.A.C.P.ROBERT H. FURMAN, M.D., F.A.C.P.Search for more papers by this author, R. PALMER HOWARD, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-5-969 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptClinicians have known for almost 200 years that the manifestations of coronary atherosclerosis are much more frequent in men than in women. Numerous autopsy studies have disclosed the disease in men earlier in life and in a more severe form than is the case with women, although anatomically this sex difference is somewhat less impressive than it is clinically. Autopsy studies on oophorectomized women, on the other hand, reveal an incidence and severity of coronary atherosclerosis more closely resembling that noted in men.1, 2Of interest and relevance are the opinions of White3and Gertler,4that there is less evidence...Bibliography1. WuestDryEdwards JHTJJE: The degree of coronary atherosclerosis in bilaterally oophorectomized women, Circulation 7: 801, 1953. CrossrefMedlineGoogle Scholar2. RivenDimitroff AUSP: The incidence and severity of atherosclerosis in estrogen-treated males, and in females with a hypoestrogenic or hyperestrogenic state, Circulation 9: 533, 1954. CrossrefMedlineGoogle Scholar3. White PD, discussion, in Barr, D. P., Russ, E. M., and Eder, H. A.: Influence of estrogens on lipoproteins in atherosclerosis, Tr. A. Am. Physicians 65: 102, 1952. MedlineGoogle Scholar4. Gertler MM: Personal communication. Google Scholar5. Eilert ML: The effects of estrogens upon the partition of the serum lipids in female patients, Am. Heart J. 38: 472, 1949. Google Scholar6. Eilert ML: The effect of estrogens upon the partition of the serum lipids in female patients, Metabolism 2: 137, 1953. MedlineGoogle Scholar7. OliverBoyd MFGS: The effect of estrogens on the plasma lipids in coronary artery disease, Am. Heart J. 47: 348, 1954. CrossrefMedlineGoogle Scholar8. OliverBoyd MFGS: The influence of the sex hormones on the circulatory lipids and lipoproteins in coronary sclerosis, Circulation 13: 82, 1956. CrossrefMedlineGoogle Scholar9. BarrRussEder DPEMHA: Influence of estrogens on lipoproteins in atherosclerosis, Tr. A. Am. Physicians 65: 102, 1952. MedlineGoogle Scholar10. Barr DP: Some chemical factors in the pathogenesis of atherosclerosis, The George E. Brown Memorial Lecture, Circulation 8: 641, 1953. CrossrefMedlineGoogle Scholar11. BarrRussEder DPEMHA: Protein-lipid relationships in plasma, in Blood cells and plasma proteins, edited by J. L. Tullis, 1953, Academic Press, New York. CrossrefGoogle Scholar12. RussEderBarr EMHADP: Influence of gonadal hormones on protein-lipid relationships in human plasma, Am. J. Med. 19: 4, 1955. CrossrefMedlineGoogle Scholar13. SteinerPaysonKendall AHFE: Effect of estrogenic hormone on serum lipids in patients with coronary atherosclerosis, Circulation 11: 784, 1955. CrossrefMedlineGoogle Scholar14. MarettVivas WCJR: The effect of oral estrogens on serum cholesterol and total lipids, U. S. Armed Forces M. J. 4: 1439, 1953. MedlineGoogle Scholar15. GitmanGreenblatt LIJ: Effect of intravenously administered estrogen in cardiovascular disease, Angiology 4: 502, 1953. CrossrefMedlineGoogle Scholar16. GertlerHudsonJost MMPBH: Effects of castration and diethylstilbestrol on the serum lipid pattern in man, Geriatrics 8: 500, 1953. MedlineGoogle Scholar17. RobinsonHiganoCohenSniffenSherer RWNWDRCJW: Effects of estrogen therapy on hormonal functions and serum lipids in men with coronary atherosclerosis, Circulation 14: 365, 1956. CrossrefMedlineGoogle Scholar18. OliverBoyd MFGS: Endocrine aspects of coronary sclerosis, Lancet 2: 1273, 1956. CrossrefGoogle Scholar19. Barr DP: Influence of sex and sex hormones upon the development of atherosclerosis and upon the lipoproteins of plasma, J. Chron. Dis. 1: 63, 1955. CrossrefMedlineGoogle Scholar20. FurmanHowardConrad RHRPLL: A preliminary study of the influence of androgenic and estrogenic steroids on the ultracentrifugal and electrophoretic patterns of the serum alpha and beta lipoproteins and globulins in eunuchoid males and postmenopausal females, Am. J. Med. 16: 594, 1954; Clin. Res. Proc. 2: 126, 1954. CrossrefGoogle Scholar21. FurmanHowardConrad RHRPLL: Alterations in serum lipoprotein distribution induced by gonadal steroids: evidence of a regulatory role of these steroids in protein-lipid association, Clin. Res. Proc. 2: 87, 1954. Google Scholar22. FurmanHowardConrad RHRPLL: The influence of androgen and estrogen in the association of lipids with serum globulins, ultracentrifugal and electrophoretic studies of problems in atherosclerosis, J. Clin. Investigation 33: 935, 1954. Google Scholar23. FurmanHowardNorciaKeaty RHRPLNEC: Influence of androgens and estrogens and related steroids on serum lipids and lipoproteins: observations in hypogonadal and normal human subjects, Am. J. Med., in press. Google Scholar24. SperryWebb WMM: A revision of the Schoenheimer-Sperry method for cholesterol determination, J. Biol. Chem. 187: 97, 1950. CrossrefMedlineGoogle Scholar25. HawkOserSummerson PBBLWH: Practical physiological chemistry, 12th Ed., 1947, The Blakiston Co., Philadelphia, p. 541. Google Scholar26. YoungburgYoungburg GEMV: Phosphorus metabolism. I. A system of blood phosphorus analysis, J. Lab. and Clin. Med. 16: 158, 1930. Google Scholar27. LewisGreenPage LAAAIH: Ultracentrifuge lipoprotein patterns of serum of normal, hypertensive and hypothyroid animals, Am. J. Physiol. 171: 391, 1952. CrossrefMedlineGoogle Scholar28. FurmanNorciaFryerWamack RHLNAWBS: Lipoprotein recovery following ultracentrifugal fractionation at solvent density 1.21 as determined by cholesterol and lipid phosphorus analyses of supernatant and bottom fractions, J. Lab. and Clin. Med. 47: 730, 1956. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Oklahoma City, Oklahoma*From the Symposium on the Pathogenesis of Coronary Heart Disease, presented at the Thirty-eighth Annual Session of The American College of Physicians, Boston, Massachusetts, April 10, 1957.From the Cardiovascular and the Endocrinology and Metabolism Sections of the Oklahoma Medical Research Foundation, and the Department of Medicine, University of Oklahoma School of Medicine, Oklahoma City, Oklahoma.This study was supported in part by research grants from the National Heart Institute (H-1429, H-1561 and H-1694) and the National Institute of Arthritis and Metabolic Diseases (A-179), the Oklahoma State Heart Association, the Ayerst Laboratories, New York, N. Y., and the Smith, Kline and French Foundation, Philadelphia.Requests for reprints should be addressed to Robert H. Furman, M.D., The Oklahoma Medical Research Foundation, 825 Northeast Thirteenth Street, Oklahoma City 4, Oklahoma. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHyperlipidaemia and premature coronary artery disease associated with sex-change in a female.Physiology of Stress and Regeneration in Job Related Cardiovascular IllnessThe Pathogenesis of HypercholesterolemiaWALTER M. BORTZ, M.D.Augmented release of hepatic triglycerides with anabolic steroids in patients with fatty liverEffect of androgens on serum lipids and lipoproteinsEffect of oxandrolone on plasma lipids and lipoproteins of patients with disorders of lipid metabolismBibliographyChapter 16. AtherosclerosisSerum lipoproteins in hydatidiform moleGonadal Hormones and Lipid MetabolismEffects of ethyl chlorophenoxyisobutyrate, alone or with androsterone (Atromid) on serum lipids, lipoproteins and related metabolic parameters in normal and hyperlipidemic subjectsHypocholesterolemic AgentsEFFECT OF BILATERAL OVARIECTOMY ON CORONARY-ARTERY DISEASE AND SERUM-LIPID LEVELSEFFECTS OF SEX STEROIDS ON LIPIDSCholesterol and Its Relation to AtherosclerosisModification of the Effects of Adrenal Cortical Steroids and Androgens on Serum Lipids and Lipoproteins by Caloric Supplementation and by Isocaloric Substitution of Carbohydrate for Dietary ProteinVariations in the Serum Total Cholesterol and Hematocrit Values in Normal Women During the Menstrual CycleREFERENCESTHE PHYSIOLOGY OF THE CIRCULATING CHOLESTEROL AND LIPOPROTEINSHormonal Aspects of Coronary Artery Disease 1 November 1957Volume 47, Issue 5Page: 969-977KeywordsAutopsyCardiology and cardiovascular diseasesCholesterolEndocrinologyHeart diseasesHormonesLipoproteinsLongitudinal studiesStable coronary artery diseaseUltracentrifugation ePublished: 1 December 2008 Issue Published: 1 November 1957 PDF downloadLoading ...