A comparison has been made of the effects of three different combined oral contraceptives (Ovulen, Anovlar, and Volidan) on the plasma levels of cholesterol, triglycerides, and total and individual phospholipids. The results indicate a difference in action between Anovlar on the one hand and of Ovulen and Volidan on the other. In three oophorectomized women the effects of one of the estrogenic and two of the progestogenic components of the combined preparations were studied separately. The drugs were given singly or in combinations and it was found that the two progestogens produced different effects as judged from the parameters studied. Norethisterone acetate influenced the plasma lipids in a direction opposite to that induced by the estrogen. These findings suggest that the overall effects on the plasma lipids induced by the various combined oral contraceptives reflect the competitional effects of the estrogenic and progestogenic components.
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Brody et al. (1968) studied this question.
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