Key result
Minute amounts of certain metal ions prolong the response of the node of Ranvier up to 5 to 6 seconds, resulting in a rectangular configuration with properties similar to heart muscle.
Population
Node of Ranvier (nerve fibers)
Design
Preclinical
Authors
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May model cardiac-like nodal responses in vitro; leaves open translation to human electrophysiology.
Addition of metal ions prolongs the electrophysiological response of the node of Ranvier, producing properties similar to those of heart muscle.
Spyropoulos et al. (1959) studied this question. Minute amounts of certain metal ions prolong the response of the node of Ranvier up to 5 to 6 seconds, resulting in a rectangular configuration with properties similar to heart muscle.
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