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September 1, 1989The Journal of PhysiologyOpen Access

Heterogeneous distribution of fast and slow potassium channels in myelinated rat nerve fibres.

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Population

Single myelinated rat nerve fibres (and intact frog nerve fibres for comparison)

Comparison

Paranodal demyelination with 0.2% pronase or… vs Before demyelination (intact node of Ranvier)

Design

Preclinical

Authors

JRJochen RöperGoethe University FrankfurtJSJürgen R. SchwarzUniversität Hamburg

Discussion

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Implication

Maps K+ channel topography in rat myelinated fibers; leaves open whether redistribution alters conduction in human neuropathies.

Structured PICO

P
Population
Single myelinated rat nerve fibres (and intact frog nerve fibres for comparison)
I
Intervention
Paranodal demyelination with 0.2% pronase or 0.2% lysolecithin added to the external solution
C
Comparator
Before demyelination (intact node of Ranvier)
O
Outcome
Potassium currents and distribution of fast and slow potassium channelssurrogate

This preclinical study demonstrates a heterogeneous distribution of fast and slow potassium channels in myelinated rat nerve fibres, with slow channels concentrated in the node and fast channels in the paranode.

Cite This Study

Röper et al. (1989) studied this question.

synapsesocial.com/papers/6a819d69ac3bbfe76d60ef1chttps://doi.org/10.1113/jphysiol.1989.sp017751
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Potassium permeability in rat myelinated nerve fibres1985 · 25 citations
  2. 2Sodium and potassium currents in acutely demyelinated internodes of rabbit sciatic nerves.1987 · 75 citations
  3. 3Potential clamp analysis of membrane currents in rat myelinated nerve fibres.1980 · 200 citations
  4. 4A quantitative description of membrane currents in rabbit myelinated nerve.1979 · 503 citations
  5. 5Macromolecular Transfer from Glia to the Axon1981 · 54 citations