Population
Single myelinated rat nerve fibres isolated from the sciatic nerve
Comparison
Potential clamp experiments, isotonic KCl… vs Normal rat node / resting potential
Design
Preclinical
Authors
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Preclinical characterization of leak currents in rat nerves leaves open their dominance in human repolarization and any therapeutic implications.
This preclinical study characterizes potassium permeability and leak currents in rat myelinated nerve fibers, demonstrating that leak currents provide the main part of the repolarizing outward current.
Brismar et al. (1985) studied this question.
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