Key result
Flurbiprofen at 0.01% and 0.1% significantly decreased the rate of vessel growth compared with vehicle controls in experimental models of corneal neovascularization.
Why the study?
Does flurbiprofen inhibit corneal neovascularization in experimental models?
Population
Two experimental models of corneal neovascularization
Comparison
Flurbiprofen sodium at concentrations of 0.01%… vs Vehicle controls and prednisolone acetate 1%
Design
Preclinical
Authors
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Hypothesis-generating for topical NSAIDs in corneal angiogenesis; human trials needed before clinical consideration.
Does flurbiprofen inhibit corneal neovascularization in experimental models?
Flurbiprofen is an effective inhibitor of corneal neovascularization in experimental models, equipotent to prednisolone.
Cooper et al. (1980) studied Corneal neovascularization. Flurbiprofen sodium vs. Vehicle controls and 1% prednisolone acetate was evaluated on Rate of vessel growth. Flurbiprofen at 0.01% and 0.1% significantly decreased the rate of vessel growth compared with vehicle controls in experimental models of corneal neovascularization.
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