Key result
Severe COPD was associated with a fast-to-slow SERCA isoform transformation in the diaphragm, including a 63% decrease in fibers expressing only fast SERCA (P<0.001) compared to controls.
Why the study?
Does severe COPD elicit a fast-to-slow SERCA isoform shift in the human diaphragm?
Case-Control (n=20)
Does severe COPD elicit a fast-to-slow SERCA isoform shift in the human diaphragm?
p-value: p=<0.001
Severe COPD is associated with a fast-to-slow SERCA isoform transformation in the diaphragm, suggesting decreased ATP utilization.
No takes yet. Share an insight, caveat, or question.
No immediate practice change in COPD; hypothesis-generating for diaphragmatic dysfunction and needs prospective validation.
Nguyen et al. (2005) conducted a case-control in Severe chronic obstructive pulmonary disease (COPD) (n=20). Severe COPD vs. Control subjects was evaluated on Expression of SERCA isoforms in diaphragm fibers (p=<0.001). Severe COPD was associated with a fast-to-slow SERCA isoform transformation in the diaphragm, including a 63% decrease in fibers expressing only fast SERCA (P<0.001) compared to controls.
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