Key result
Moderate to severe COPD was associated with a 16% lower maximal Ca2+-ATPase activity in skeletal muscle compared to healthy controls (133 vs 158 µmol/g protein/min, P<0.05).
Why the study?
Do patients with moderate to severe COPD have altered sarcoplasmic reticulum Ca2+-cycling properties in skeletal muscle compared to healthy controls?
Case-Control (n=18)
Do patients with moderate to severe COPD have altered sarcoplasmic reticulum Ca2+-cycling properties in skeletal muscle compared to healthy controls?
Effect estimate: 16% lower
Absolute Event Rate: 133% vs 158%
p-value: p=< 0.05
Moderate to severe COPD is associated with reduced skeletal muscle sarcoplasmic reticulum Ca2+-ATPase activity and Ca2+ uptake, suggesting impaired Ca2+ cycling.
Authors
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May suggest impaired Ca2+ cycling contributes to muscle dysfunction in COPD; leaves open causal and therapeutic implications.
Green et al. (2008) conducted a case-control in Chronic obstructive pulmonary disease (COPD) (n=18). Moderate to severe COPD vs. Healthy age-matched controls was evaluated on Maximal Ca2+-ATPase activity (Vmax) (16% lower, p=< 0.05). Moderate to severe COPD was associated with a 16% lower maximal Ca2+-ATPase activity in skeletal muscle compared to healthy controls (133 vs 158 µmol/g protein/min, P<0.05).
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