Key result
In patients with cardiac and vascular disease, pericardial fluid is significantly enriched in adipocyte fatty acid-binding protein (73 vs 8.4 μg/L) and poor in adiponectin (2.8 vs 13 mg/L) compared to venous plasma.
Cross-Sectional (n=37)
No
In patients with cardiovascular disease, the pericardial fluid is enriched in atherogenic A-FABP and depleted of protective adiponectin compared to systemic circulation, suggesting a localized pro-inflammatory microenvironment.
Pericardial adipokine imbalance may reflect local inflammation in CVD; hypothesis-generating and requires prospective validation before clinical relevance.
AIM: Obesity and especially hypertrophy of epicardial adipose tissue accelerate coronary atherogenesis. We aimed at comparing levels of inflammatory and atherogenic hormones from adipose tissue in the pericardial fluid and circulation of cardiovascular disease patients. METHODS AND RESULTS: Venous plasma (P) and pericardial fluid (PF) were obtained from elective cardiothoracic surgery patients (n = 37). Concentrations of leptin, adipocyte fatty acid-binding protein (A-FABP) and adiponectin (APN) were determined by enzyme-linked immunosorbent assays (ELISA). The median concentration of leptin in PF (4.3 (interquartile range: 2.8-9.1) μg/L) was comparable to that in P (5.9 (2.2-11) μg/L) and these were significantly correlated to most of the same patient characteristics. The concentration of A-FABP was markedly higher (73 (28-124) versus 8.4 (5.2-14) μg/L) and that of APN was markedly lower (2.8 (1.7-4.2) versus 13 (7.2-19) mg/L) in PF compared to P. APN in PF was unlike in P not significantly related to age, body mass index, plasma triglycerides or coronary artery disease. PF levels of APN, but not A-FABP, were related to the size of paracardial adipocytes. PF levels of APN and A-FABP were not related to the immunoreactivity of paracardial adipocytes for these proteins. CONCLUSION: In cardiac and vascular disease patients, PF is enriched in A-FABP and poor in APN. This adipokine microenvironment is more likely determined by the heart than by the circulation or paracardial adipose tissue.
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Elie et al. (2016) conducted a cross-sectional in Cardiac and vascular disease (n=37). Pericardial fluid vs. Venous plasma was evaluated on Concentration of adipocyte fatty acid-binding protein (A-FABP) (p=<0.0001). In patients with cardiac and vascular disease, pericardial fluid is significantly enriched in adipocyte fatty acid-binding protein (73 vs 8.4 μg/L) and poor in adiponectin (2.8 vs 13 mg/L) compared to venous plasma.
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