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December 31, 2009Adipobiology

Adipokine concentrations are similar in femoral artery and coronary venous sinus blood: evidence against in vivo endocrine secretion by human epicardial fat

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Key result

Adipokine concentrations did not differ significantly between femoral arterial and coronary sinus venous blood, suggesting epicardial fat does not secrete adipokines into coronary blood in vivo.

Why the study?

Does human epicardial fat secrete adipokines into coronary blood under basal conditions in vivo?

Population

n=11 patients, mostly young non-obese women, without known heart disease undergoing cardiac catheterisation…

Comparison

Measurement of adipokines in coronary sinus… vs Measurement of adipokines in femoral arterial…

Design

Cross-sectional

Authors

HSHarold S. SacksRegeneron (United States)EJEric E. JohnsonThe Stern Cardiovascular Foundation

Discussion

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Member takes

Overview

Does not support epicardial fat as coronary endocrine source of adipokines; leaves open its paracrine effects in local cardiac regulation.

Study Design

Type

Observational (n=11)

Structured PICO

Does human epicardial fat secrete adipokines into coronary blood under basal conditions in vivo?

P
Population
11 patients, mostly young non-obese women, without known heart disease undergoing cardiac catheterisation for radioablation of supraventricular tachycardia.
E
Exposure
Measurement of adipokines in coronary sinus venous blood
C
Comparator
Measurement of adipokines in femoral arterial blood (surrogate for coronary arterial blood)
O
Outcome
Mean adipokine concentrations (Adiponectin, leptin, resistin, tumor necrosis factor-α, monocyte chemoattractant protein-1, active plasminogen-activator inhibitor-1, interleukin-1β, -6, -8 and vascular endothelial growth factor)surrogate

Human epicardial adipose tissue does not appear to secrete adipokines into coronary blood under basal conditions in vivo, suggesting these molecules function primarily as local paracrine regulators.

Limitations

  • Values for several adipokines were below the assay detection limit in several patients negating the use of regression analysis.
  • Values for several adipokines were below the assay detection limit in several patients, negating the use of regression analysis

Cite This Study

Sacks et al. (2009) conducted an observational in Supraventricular tachycardia without known heart disease (n=11). Coronary sinus venous blood vs. Femoral arterial blood was evaluated on Mean adipokine concentrations. Adipokine concentrations did not differ significantly between femoral arterial and coronary sinus venous blood, suggesting epicardial fat does not secrete adipokines into coronary blood in vivo.

synapsesocial.com/papers/6a9bcaa34bbfaa90c7850363https://doi.org/10.14748/adipo.v1.249
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