Key result
Genetic analysis of 131 Parechovirus-A3 strains in Japan revealed alternate dominant clusters during epidemic years and estimated the year of viral emergence to be 1991.
Why the study?
Parechovirus-A3 has been identified worldwide but its epidemiological characteristics differ by region.
Observational (n=131)
Genetic analysis of PeV-A3 strains in Japan reveals changing epidemic patterns and estimates the virus's emergence to 1991, highlighting the need for continuous molecular surveillance.
Supports molecular surveillance of PeV-A3; leaves open drivers of epidemic cycles and clinical impact.
Parechovirus-A3 (PeV-A3), first reported in 2004 in Japan, is an emerging pathogen that causes sepsis and meningoencephalitis in neonates and young infants. Although PeV-A3 has been identified worldwide, its epidemiological characteristics differ by region. To investigate the molecular evolution and epidemiology of PeV-A3, we performed genetic analyses of 131 PeV-A3 strains from the years 1997-2019 in Niigata, Japan. During 2016-2019, annual numbers remained steady, in contrast to the PeV-A3 epidemic interval of every 2-3 years that was observed in Japan from 2006. Bayesian evolutionary analysis of the complete viral protein 1 region revealed alternate dominant clusters during years of PeV-A3 epidemics. The branch including the oldest and first isolated PeV-A3 strains in Japan has been disrupted since 2001. The year of PeV-A3 emergence was estimated to be 1991. Continuous surveillance with genetic analyses of different regions will improve understanding of PeV-A3 epidemiology worldwide.
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Aizawa et al. (2022) conducted an observational in Parechovirus-A3 infection (n=131). Parechovirus-A3 strains was evaluated on Molecular evolution and epidemiology of PeV-A3. Genetic analysis of 131 Parechovirus-A3 strains in Japan revealed alternate dominant clusters during epidemic years and estimated the year of viral emergence to be 1991.
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