Key result
The 27bp-VNTR rare allele (4a) of the eNOS gene was significantly associated with decreased HDL-C (p=0.04) and increased diastolic blood pressure (p=0.02) in Mexican Americans.
Why the study?
Are eNOS gene polymorphisms associated with type 2 diabetes and related traits in Mexican Americans?
Population
670 Mexican Americans (39 families) at high risk for type 2 diabetes and its complications
Design
Cross-sectional
Authors
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eNOS 4a association with HDL-C and DBP is hypothesis-generating in Mexican Americans; should not change practice pending replication.
Observational (n=670)
Are eNOS gene polymorphisms associated with type 2 diabetes and related traits in Mexican Americans?
p-value: p=0.04 (HDL-C), 0.02 (DBP)
The 27bp-VNTR polymorphism of the eNOS gene is a minor contributor to variations in HDL-C and diastolic blood pressure in Mexican Americans.
Thameem et al. (2008) conducted an observational in Type 2 diabetes and related traits (n=670). eNOS gene polymorphisms (T-786C, Glu298Asp, 27bp-VNTR) vs. Non-carriers was evaluated on Type 2 diabetes and related phenotypes (including HDL-C and DBP) (p=0.04 (HDL-C), 0.02 (DBP)). The 27bp-VNTR rare allele (4a) of the eNOS gene was significantly associated with decreased HDL-C (p=0.04) and increased diastolic blood pressure (p=0.02) in Mexican Americans.
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