Key result
eNOS gene polymorphisms were not significantly associated with ischemic heart disease after multiple testing correction, despite initial subgroup associations (e.g., RR 3.67 in type A behavior).
Why the study?
Are eNOS gene polymorphisms associated with ischemic heart disease in the Spanish population?
Population
101 nuclear families having one affected offspring of ischemic heart disease (IHD) in Spain
Design
Other
Authors
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No association after correction in Spanish cohort; leaves open eNOS role in IHD subgroups and requires larger replication studies.
Observational (n=101)
Are eNOS gene polymorphisms associated with ischemic heart disease in the Spanish population?
p-value: p=nonsignificant
eNOS gene polymorphisms (ecNOS4a/b VNTR and G894T) do not appear to be significantly associated with ischemic heart disease in the Spanish population after correcting for multiple testing.
Vía et al. (2002) conducted an observational in Ischemic heart disease (n=101). eNOS gene polymorphisms (ecNOS4a/b VNTR and G894T substitution) was evaluated on Ischemic heart disease (p=nonsignificant). eNOS gene polymorphisms were not significantly associated with ischemic heart disease after multiple testing correction, despite initial subgroup associations (e.g., RR 3.67 in type A behavior).
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