Key result
Preoperative use of B-blockers was associated with a significantly reduced risk of postoperative junctional ectopic tachycardia (OR 0.2) in children under 2 years undergoing tetralogy of Fallot repair.
Why the study?
Does postoperative junctional ectopic tachycardia prolong ICU and hospital stay in children under 2 years undergoing tetralogy of Fallot repair?
Cohort (n=322)
No
Does postoperative junctional ectopic tachycardia prolong ICU and hospital stay in children under 2 years undergoing tetralogy of Fallot repair?
Odds Ratio: 0.2 (95% CI 0.08–0.51)
Absolute Event Rate: 19.5% vs 33.1%
p-value: p=0.001
Postoperative junctional ectopic tachycardia is common after tetralogy of Fallot repair in children under 2 years and significantly prolongs ICU stay, highlighting the importance of preoperative beta-blockers and aggressive electrolyte management.
May support preoperative beta-blockers to lower JET risk in young TOF patients; hypothesis-generating and requires RCT confirmation.
BACKGROUND: Junctional ectopic tachycardia is a serious arrhythmia that frequently occurs after tetralogy of Fallot repair. Arrhythmia prophylaxis is not feasible for all pediatric cardiac surgery patients and identification of high risk patients is required. The objectives of this study were to characterize patients with JET, identify its predictors and subsequent complications and the effect of various treatment strategies on the outcomes in selected TOF patients undergoing total repair before 2 years of age. METHODS: From 2003 to 2017, 609 patients had Tetralogy of Fallot repair, 322 were included in our study. We excluded patients above 2 years and patients with preoperative arrhythmia. 29.8% of the patients (n = 96) had postoperative JET. RESULTS: JET patients were younger and had higher preoperative heart rate. Independent predictors of JET were younger age, higher preoperative heart rate, cyanotic spells, non-use of B-blockers and low Mg and Ca (p = 0.011, 0.018, 0.024, 0.001, 0.004 and 0.001; respectively). JET didn't affect the duration of mechanical ventilation nor hospital stay (p = 0.12 and 0.2 respectively) but prolonged the ICU stay (p = 0.011). JET resolved in 39.5% (n = 38) of patients responding to conventional measures. Amiodarone was used in 31.25% (n = 30) of patients and its use was associated with longer ICU stay (p = 0.017). Ventricular pacing was required in 4 patients (5.2%). Median duration of JET was 30.5 h and 5 patients had recurrent JET episode. Timing of JET onset didn't affect ICU (p = 0.43) or hospital stay (p = 0.14) however, long duration of JET increased ICU and hospital stay (p = 0.02 and 0.009; respectively). CONCLUSION: JET increases ICU stay after TOF repair. Preoperative B-blockers significantly reduced JET. Patients with preoperative risk factors could benefit from preoperative arrhythmia prophylaxis and aggressive management of postoperative electrolyte disturbance is essential.
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Ismail et al. (2018) conducted a cohort in Tetralogy of Fallot (n=322). Preoperative B-blockers vs. No preoperative B-blockers was evaluated on Postoperative junctional ectopic tachycardia (JET) (OR 0.2, 95% CI 0.08-0.51, p=0.001). Preoperative use of B-blockers was associated with a significantly reduced risk of postoperative junctional ectopic tachycardia (OR 0.2) in children under 2 years undergoing tetralogy of Fallot repair.
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