Key result
In patients with chronic kidney disease, being in the highest tertiles for both urinary angiotensinogen-to-creatinine ratio and 24-hour urinary sodium excretion was associated with being in the highest systolic blood pressure tertile (OR 2.4).
Why the study?
Does enhanced intrarenal RAS activity (indicated by high UAGT/Cr) and high dietary sodium (indicated by high 24-hour UNa) associate with elevated systolic blood pressure in patients with CKD?
Does enhanced intrarenal RAS activity (indicated by high UAGT/Cr) and high dietary sodium (indicated by high 24-hour UNa) associate with elevated systolic blood pressure in patients with CKD?
Odds Ratio: 2.4
Urinary angiotensinogen and 24-hour urinary sodium excretion are associated with elevated systolic blood pressure in patients with chronic kidney disease, highlighting the role of intrarenal RAS activity and salt sensitivity.
See the article "Effect of urinary angiotensinogen and high-salt diet on blood pressure in patients with chronic kidney disease: results from the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease (KNOW-CKD)" in volume 36 on page 659.
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Jung et al. (2021) conducted an editorial in Chronic kidney disease (n=1,955). High urinary angiotensinogen-to-creatinine ratio (UAGT/Cr) and high 24-hour urinary sodium (UNa) vs. Lower tertiles of UAGT/Cr and 24-hour UNa was evaluated on Highest systolic blood pressure tertile (OR 2.4). In patients with chronic kidney disease, being in the highest tertiles for both urinary angiotensinogen-to-creatinine ratio and 24-hour urinary sodium excretion was associated with being in the highest systolic blood pressure tertile (OR 2.4).
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