Key result
General anesthesia in school-age children was not associated with an increased risk of postoperative cognitive dysfunction on day 1 compared to age-matched controls (adjusted RRR 0.85).
Why the study?
Does general anesthesia cause postoperative cognitive dysfunction in school-age children undergoing elective noncardiac surgery?
Population
244 school children aged 5 to 12 years, including 118 undergoing elective noncardiac surgery and 126…
Comparison
General anesthesia for elective noncardiac surgery vs Age-matched controls not undergoing surgery or…
Design
Cohort
Follow-up
6 weeks
Authors
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Reassures on short-term cognitive safety with general anesthesia in school-age children; leaves open longer-term effects and causality.
Cohort (n=244)
Does general anesthesia cause postoperative cognitive dysfunction in school-age children undergoing elective noncardiac surgery?
Relative Risk: 0.85 (95% CI 0.1–7.05)
Absolute Event Rate: 5.1% vs 4%
p-value: p=0.88
General anesthesia for elective noncardiac surgery in school-age children is associated with a low incidence of postoperative cognitive dysfunction and only transient effects on visual matching.
Aun et al. (2016) conducted a cohort in Postoperative cognitive dysfunction (n=244). General anesthesia vs. Age-matched controls (no anesthesia) was evaluated on Incidence of postoperative cognitive dysfunction (POCD) on Day 1 (RRR 0.85, 95% CI 0.10-7.05, p=0.88). General anesthesia in school-age children was not associated with an increased risk of postoperative cognitive dysfunction on day 1 compared to age-matched controls (adjusted RRR 0.85).
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