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Anticolon carcinoma antibodies were produced in rabbits against a cytoplasmic extract of a single colon carcinoma. Immunofluorescent staining and precipitin inhibition studies, using these antibodies, showed a clear separation of colon carcinomas from normal colon, inflammatory conditions of the colon and colonic polyps. This study suggests that colon carcinoma has at least 3 antigens capable of stimulating antibody production in rabbits. Two of the antigens are shared with normal colon and ulcerative colitis. The third appears to be specific for colon carcinoma within the limits of detection by direct immunofluorescent staining.
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Norland et al. (1969) studied this question.
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