Why the study?
Does point-of-care monitoring with ACT or HMT accurately reflect high-dose heparin levels compared to anti-Xa activity in patients undergoing extracorporeal circulation?
Population
8 patients undergoing cardiovascular surgery with extracorporeal circulation (ECC), providing 40 samples
Comparison
Point-of-care monitoring of high-dose heparin… vs Heparin levels measured as anti-Xa activity
Design
Cross-sectional
Authors
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Neither POC test should guide high-dose heparin dosing in extracorporeal circulation; leaves open need for validated alternatives.
Does point-of-care monitoring with ACT or HMT accurately reflect high-dose heparin levels compared to anti-Xa activity in patients undergoing extracorporeal circulation?
Point-of-care ACT and HMT monitors show poor diagnostic accuracy for measuring high-dose heparin effects during extracorporeal circulation compared to anti-Xa levels.
Giavarina et al. (2002) studied this question.
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