Key result
The Heparin Management Test (HMT) correlated significantly with standard activated clotting time (ACT) values in patients undergoing balloon angioplasty (r = 0.6; P < 0.01).
Why the study?
Does the Heparin Management Test correlate with the activated clotting time for monitoring heparin anticoagulation in patients undergoing angioplasty?
Observational (n=50)
Does the Heparin Management Test correlate with the activated clotting time for monitoring heparin anticoagulation in patients undergoing angioplasty?
Effect estimate: r = 0.6
Absolute Event Rate: 286% vs 283%
p-value: p=<0.01
The Heparin Management Test correlates well with standard ACT values for monitoring heparin during percutaneous transluminal coronary angioplasty.
May support HMT for heparin monitoring in angioplasty; leaves open prospective validation before clinical adoption.
The aim of this study was to compare the activated clotting time (ACT) obtained with the Hemochron device and the Heparin Management Test (HMT) on a new automated whole-blood coagulometer, the Thrombolytic Assessment System, in patients undergoing angioplasty. Fifty patients undergoing balloon angioplasty were prospectively enrolled. The mean ACT after a 10,000 unit bolus of heparin was 283 +/- 39 sec at the end of the procedure. The mean HMT after 10,000 units of heparin was 286 +/- 31 sec at the end of the procedure in the same patients. The correlation between the two methods was significant (r = 0.6; P < 0.01). The HMT appears to correlate well with standard values obtained with the Hemochron ACT monitor in patients undergoing percutaneous transluminal coronary angioplasty.
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Helft et al. (1998) conducted an observational in Percutaneous transluminal coronary angioplasty (n=50). Heparin Management Test (HMT) vs. Activated clotting time (ACT) with Hemochron device was evaluated on Correlation between HMT and ACT at the end of the procedure (r = 0.6, p=<0.01). The Heparin Management Test (HMT) correlated significantly with standard activated clotting time (ACT) values in patients undergoing balloon angioplasty (r = 0.6; P < 0.01).
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