Key result
Comprehensive rehabilitation programs with lifestyle interventions initiated within 90 days of a TIA or minor stroke showed no significant effect on resting systolic blood pressure, resting heart rate, aerobic capacity, falls, or mortality compared to usual care.
Why the study?
Do secondary prevention lifestyle interventions initiated within 90 days improve modifiable risk factors or functioning in patients post-TIA or minor stroke?
Meta-Analysis (n=774)
Do secondary prevention lifestyle interventions initiated within 90 days improve modifiable risk factors or functioning in patients post-TIA or minor stroke?
Mean Difference: 1.3 (95% CI -17.39–19.99)
p-value: p=0.87
There is limited evidence for the effectiveness of early post-TIA rehabilitation programmes with preventive lifestyle interventions, with no significant improvements seen in risk factors or mortality.
Early post-TIA rehabilitation shows no effect on blood pressure or mortality; challenges implementation and supports targeted research on effective components.
BACKGROUND: Strokes are often preceded by a transient ischaemic attack (TIA) or 'minor' stroke. The immediate period after a TIA/minor stroke is a crucial time to initiate secondary prevention. However, the optimal approach to prevention, including non-pharmacological measures, after TIA is not clear. AIM: To systematically review evidence about the effectiveness of delivering secondary prevention, with lifestyle interventions, in comprehensive rehabilitation programmes, initiated within 90 days of a TIA/minor stroke. Also, to categorise the specific behaviour change techniques used. DESIGN AND SETTING: The review identified randomised controlled trials by searching the Cochrane Library, Ovid MEDLINE, Ovid EMBASE, Web of Science, EBSCO CINAHL and Ovid PsycINFO. METHOD: Two review authors independently screened titles and abstracts for eligibility (programmes initiated within 90 days of event; outcomes reported for TIA/minor stroke) and extracted relevant data from appraised studies; a meta-analysis was used to synthesise the results. RESULTS: A total of 31 potentially eligible papers were identified and four studies, comprising 774 patients post-TIA or minor stroke, met the inclusion criteria; two had poor methodological quality. Individual studies reported increased aerobic capacity but meta-analysis found no significant change in resting and peak systolic blood pressure, resting heart rate, aerobic capacity, falls, or mortality. The main behaviour change techniques were goal setting and instructions about how to perform given behaviours. CONCLUSION: There is limited evidence of the effectiveness of early post-TIA rehabilitation programmes with preventive lifestyle interventions. Further robust randomised controlled trials of comprehensive rehabilitation programmes that promote secondary prevention and lifestyle modification immediately after a TIA are needed.
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Heron et al. (2016) conducted a meta-analysis in Transient ischaemic attack (TIA) or minor stroke (n=774). Comprehensive rehabilitation programmes with secondary prevention lifestyle interventions vs. Usual care or verbal information was evaluated on Resting systolic blood pressure (mmHg) (MD 1.30, 95% CI -17.39 to 19.99, p=0.87). Comprehensive rehabilitation programs with lifestyle interventions initiated within 90 days of a TIA or minor stroke showed no significant effect on resting systolic blood pressure, resting heart rate, aerobic capacity, falls, or mortality compared to usual care.
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