Why the study?
Does human aortic intima extract affect ADP- or epinephrine-induced platelet aggregation in vitro?
Population
Human aortas obtained at autopsy within 5 hours of death from 5 subjects, aged 40 to 49 years.
Comparison
Extract of human uninvolved aortic intima vs ADP or epinephrine alone (without extract)
Design
Preclinical
Authors
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May suggest complex vascular-platelet interactions in atherosclerosis; leaves open human relevance pending further study.
Does human aortic intima extract affect ADP- or epinephrine-induced platelet aggregation in vitro?
Human aortic intima extract inhibits ADP-induced platelet aggregation but potentiates epinephrine-induced aggregation, suggesting complex roles in thrombosis and atherosclerosis.
Izawa et al. (1984) studied this question.
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