Key result
Challenge with virulent viruses successfully replaced the initial persisting virus in BHK-21 cell cultures, demonstrating that virulence can facilitate viral reestablishment in persistent infections.
Population
BHK-21 cells persistently infected with foot-and-mouth disease virus of serotype C (clone C-S8c1)
Design
Preclinical
Authors
Loading...
Virulence may aid viral reestablishment in persistent cell models; leaves open in vivo or clinical relevance.
Virulence can be a positive factor in the reestablishment of a virus population in a persistently infected cell culture.
Sáiz et al. (1996) studied Foot-and-mouth disease virus persistence. Challenge with virulent virus variants vs. Challenge with parental virus or mutant rescued after prolonged persistence was evaluated on Composition of the resident virus population (replacement of resident virus). Challenge with virulent viruses successfully replaced the initial persisting virus in BHK-21 cell cultures, demonstrating that virulence can facilitate viral reestablishment in persistent infections.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: