Is the Automatic Atrial Defibrillator a Promising Approach?

Jerry C. Griffin; Gregory M. Ayers; John Adams; Clif A. Alferness; ROSS INFINGER; STEVE ADLER; VICTOR CHEN

doi:10.1111/j.1540-8167.1996.tb00501.x

December 1, 1996Journal of Cardiovascular Electrophysiology

Is the Automatic Atrial Defibrillator a Promising Approach?

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Why the study?

Does an automatic atrial defibrillator improve conversion of atrial fibrillation in patients with recurring episodes of persistent, drug-refractory atrial fibrillation?

Key Points

To evaluate the feasibility, safety, and clinical potential of automatic implantable atrial defibrillators in treating persistent, drug-refractory atrial fibrillation.
Reviewed preclinical animal studies demonstrating the feasibility of internal atrial defibrillation using intravenous electrodes.
Assessed clinical studies testing synchronized low-energy electrical shocks delivered during specific R-wave timing windows.
Low-energy intravenous shocks successfully restore normal sinus rhythm from atrial fibrillation.
Shock delivery remains safe when properly synchronized to the R wave in the absence of a short preceding RR interval.
Early clinical experience indicates small implantable devices offer a viable therapeutic option for persistent, drug-refractory episodes.

Structured PICO

Does an automatic atrial defibrillator improve conversion of atrial fibrillation in patients with recurring episodes of persistent, drug-refractory atrial fibrillation?

P

Population

Patients with recurring episodes of persistent, drug-refractory atrial fibrillation (and animal models)

I

Intervention

Automatic atrial defibrillator delivering low-energy shocks synchronous to the R wave

O

Outcome

Conversion of atrial fibrillation

An implanted automatic atrial defibrillator delivering low-energy shocks synchronous to the R wave shows promise for treating persistent, drug-refractory atrial fibrillation.

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Implication

Supports investigation of automatic atrial defibrillators for refractory AF; leaves open their role pending controlled trials.

Abstract

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Discussion

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Cite This Study

Griffin et al. (1996) studied this question.

synapsesocial.com/papers/6a972f0cfcabbc0bcaaf5cb1 https://doi.org/10.1111/j.1540-8167.1996.tb00501.x

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Is the Automatic Atrial Defibrillator a Promising Approach?

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Is the Automatic Atrial Defibrillator a Promising Approach?

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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