Key result
Atrial contraction at an optimal AS-VS interval increased left ventricular end-diastolic pressure by 12.2 cm H2O, stroke volume by 27 ml, and stroke work by 33 g-m versus no atrial contribution.
Why the study?
Does optimal atrial contraction timing improve ventricular performance in a complete heart block preparation?
Population
Complete heart block preparation (experimental model)
Comparison
Atrial contraction at an AS-VS interval with… vs AS-VS interval with no atrial contribution
Design
Preclinical
Authors
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Optimal atrial timing augments ventricular performance in animal heart block models; leaves open translation to clinical AV synchrony.
Does optimal atrial contraction timing improve ventricular performance in a complete heart block preparation?
Optimal timing of atrial contraction significantly augments ventricular performance by increasing end-diastolic pressure and fiber length, demonstrating the hemodynamic importance of AV synchrony.
Stanley K. Brockman (1963) studied this question. Atrial contraction at optimal AS-VS interval vs. AS-VS interval with no atrial contribution was evaluated on Left ventricular performance (end-diastolic pressure, fiber length, aortic pressure, stroke volume, stroke work). Atrial contraction at an optimal AS-VS interval increased left ventricular end-diastolic pressure by 12.2 cm H2O, stroke volume by 27 ml, and stroke work by 33 g-m versus no atrial contribution.
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