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March 15, 2006The Journal of Clinical PsychiatryOpen Access

Methodological Issues in a Study of Long-Term Maintenance Therapy With Quetiapine Versus Haloperidol Decanoate

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Authors

BABabatunde AdetunjiUniversity of Ibadan BBBiju BasilMiles College MMMaju MathewsMadras Medical College

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Implication

Critical commentary reports methodological design flaws in schizophrenia maintenance therapy, highlighting potential favorability bias toward quetiapine.

Key Points

Critique the study design and statistical validity of a trial evaluating long-term maintenance therapy with quetiapine versus haloperidol decanoate in schizophrenia and schizoaffective disorders.
Critically reviewed an open-label trial comparing oral quetiapine with intramuscular haloperidol decanoate for long-term maintenance.
Evaluated the statistical computations and potential sources of systematic favorability bias.
Contrasting an oral atypical antipsychotic with an intramuscular conventional agent in an unblinded design introduces high risk of bias favoring quetiapine.
Deficiencies in methodology and statistical calculations prevent drawing valid conclusions regarding the relative efficacy and side-effect profiles of the treatments.

Cite This Study

Adetunji et al. (2006) studied this question.

synapsesocial.com/papers/6a97301d570fc54467ccd27b https://doi.org/10.4088/jcp.v67n0323d

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Implication

Critical commentary reports methodological design flaws in schizophrenia maintenance therapy, highlighting potential favorability bias toward quetiapine.

Methodological Issues in a Study of Long-Term Maintenance Therapy With Quetiapine Versus Haloperidol Decanoate

Discussion

Member takes

Implication

Key Points

Cite This Study

Methodological Issues in a Study of Long-Term Maintenance Therapy With Quetiapine Versus Haloperidol Decanoate

Discussion

Member takes

Implication

Key Points

Cite This Study

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