Key result
Increasing sodium chloride caused spontaneous contraction and potentiated the contractile response to catecholamines, while total removal depressed contractility in dog aortic strips.
Why the study?
Does varying sodium chloride concentration affect the contractile response of dog aortic strips to catecholamines?
Does varying sodium chloride concentration affect the contractile response of dog aortic strips to catecholamines?
Sodium concentration modulates the contractile response of aortic tissue to catecholamines, suggesting a potential mechanism for sodium's role in hypertension.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for sodium's vascular effects in animals; leaves open any relevance to human hypertension.
Effect of sodium ion on the dog's aortic strip was determined by measuring the tension produced by the isometric contraction of the strip in response to catecholamines during the incubation in Krebs' solution and in modified Krebs' solution in which the concentration of sodium chloride was varied. It was found that increasing sodium chloride in the solution to a certain amount, itself caused spontaneous contraction of the strip. The subthreshold addition of sodium chloride to Krebs' solution in an amount incapable of causing spontaneous contraction definitely potentiated the contractile response of the strip to a low concentration of catecholamines. Total removal of sodium chloride from Krebs' solution considerably depressed the contractility of the strip in response to catecholamines. It is suggested that sodium may importantly be involved in the development of some type of hypertension.
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Yamabayashi et al. (1959) studied this question. Sodium chloride concentration variation vs. Standard Krebs' solution was evaluated on Tension produced by isometric contraction in response to catecholamines. Increasing sodium chloride caused spontaneous contraction and potentiated the contractile response to catecholamines, while total removal depressed contractility in dog aortic strips.
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