Key result
Elevated circulating levels of TIMP-1 at 24 hours post-myocardial infarction were independently associated with an increased risk of acute heart failure in men (OR 5.57).
Why the study?
Are TIMP-1 levels and gene polymorphisms associated with acute heart failure and left ventricular dysfunction in STEMI patients treated with primary PCI?
Observational (n=556)
No
Are TIMP-1 levels and gene polymorphisms associated with acute heart failure and left ventricular dysfunction in STEMI patients treated with primary PCI?
Higher circulating TIMP-1 levels, but not the exon 5 SNP rs4898 polymorphism, are independently associated with worse ejection fraction and acute heart failure in men following STEMI treated with primary PCI.
AIMS: Tissue inhibitors of metalloproteinase (TIMPs) bind to active matrix metalloproteinase (MMPs), and thereby inhibit their proteolytic activity. We investigated the role of polymorphisms in the gene for TIMP-1 and serum levels of TIMP-1 in association with postmyocardial infarction (MI), left ventricular (LV) dysfunction, and symptoms of acute heart failure (AHF) in patients treated with primary percutaneous coronary intervention. METHODS: In total, 556 patients with STEMI were evaluated. Levels of TIMP-1 were measured at admission and 24 h after MI onset. The TIMP-1 exon 5 SNP rs4898 (F124F with T>C) located at X chromosome was assayed. RESULTS: TIMP-1 levels were higher for men with AHF as well as for men with LV dysfunction (ejection fraction [EF]<40%). According to multivariate analysis, the TIMP-1 level was a factor with an independent negative relationship to EF and AHF in men. An independent relationship between exon 5 TIMP-1 gene polymorphism and EF, AHF or TIMP-1 level was not documented. CONCLUSION: These results provide evidence that a higher level of circulating TIMP-1 is independently associated with worse EF and AHF.
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Goldbergová et al. (2012) conducted an observational in ST Elevation Myocardial Infarction (STEMI) (n=556). Elevated TIMP-1 levels at 24 hours vs. Lower TIMP-1 levels was evaluated on Acute heart failure in men (OR 5.570, 95% CI 2.089-14.850, p=0.001). Elevated circulating levels of TIMP-1 at 24 hours post-myocardial infarction were independently associated with an increased risk of acute heart failure in men (OR 5.57).
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