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September 2, 2022Seminars in Thrombosis and Hemostasis

Activated Partial Thromboplastin Time and Prothrombin Time Mixing Studies: Current State of the Art

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Key result

This review highlights the lack of standardization in aPTT and PT mixing studies and describes common indications, preanalytic variables, and interpretation methods for these tests.

Why the study?

There is a lack of standardization for both the testing protocol and the interpretation of corrected versus noncorrected aPTT and PT mixing studies.

Design

Review

Authors

DADorothy AdcockOffice of the Chief ScientistGMGary MooreNational Health ServiceSMSilmara Aparecida de Lima MontalvãoUniversidade Estadual de Campinas (UNICAMP)

Discussion

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Implication

Inconsistent mixing study protocols may lead to variable clinical interpretations; leaves open the need for evidence-based standardization.

PICO

P
Population
Prolonged activated partial thromboplastin time (aPTT) or prothrombin time (PT)
E
Exposure / Comparator
aPTT and PT mixing studies

This review highlights the lack of standardization in aPTT and PT mixing studies and discusses indications, preanalytic variables, and interpretation methods.

Limitations

  • Lack of standardization for both the testing protocol and the interpretation of what is considered to be a corrected or noncorrected mixing study result

Cite This Study

Adcock et al. (2022) conducted a review in Prolonged activated partial thromboplastin time (aPTT) or prothrombin time (PT). aPTT and PT mixing studies was evaluated. This review highlights the lack of standardization in aPTT and PT mixing studies and describes common indications, preanalytic variables, and interpretation methods for these tests.

synapsesocial.com/papers/6a97347bb76967a4eb3c04c6https://doi.org/10.1055/s-0042-1756196
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