Key result
Type 2 diabetes cases exhibited a 6.67-fold increase in lncRNA LINC01173 expression compared to healthy controls, with higher expression significantly associated with vitamin-D deficiency and smoking.
Why the study?
The role of long noncoding RNAs in the onset and progression of type 2 diabetes mellitus, alongside the role of vitamins, requires investigation.
Case-Control
Increased lncRNA LINC01173 expression in T2DM is associated with vitamin-D deficiency, smoking, and altered glycemic control.
This is the authors' abstract. We don't add key points for this paper.
Background: Type 2 diabetes mellitus (T2DM) has risen to become the world’s most serious public health problem in recent years, and the role of long noncoding RNAs (lncRNAs) in the onset and progression of T2DM, as well as special attention to vitamins, has gotten a lot of attention recently. Methods: The aim of the study was to analyze lncRNA LINC01173 expression along with assessment of vitamin-D and B12 among the T2DM cases. Quantitative RT-PCR was used to analyze the expression of lncRNA LINC01173. Vitamin-D and B12 were analyzed by chemiluminescence-based assay. Results: The present study observed that the T2DM cases had 6.67-fold increased lncRNA LINC01173 expression compared to healthy controls. Expression of lncRNA LINC01173 was found to be associated with hypertension ( p =0.03), wound healing ( p =0.04), and blurred vision ( p < 0.0001). It was observed that the T2DM cases with vitamin-D deficiency had a significant association with fasting glucose level ( p =0.01) and HbA1C level ( p =0.01) among the T2DM cases. The association of lncRNA LINC01173 with vitamin-D was analyzed and it was observed that the vitamin-D deficient cases had higher lncRNA LINC01173 expression compared to insufficient T2DM cases ( p =0.01) and sufficient T2DM cases ( p =0.0006). It was also observed that the T2DM cases with smoking had a 8.33-fold lncRNA LINC01173 expression while non-smokers had a 5.43-fold lncRNA LINC01173 expression ( p < 0.0001). Conclusion: The study concluded that the increased lncRNA LINC01173 expression was observed to be linked with alteration in vitamin-D level and smoking habit. Altered expression of lncRNA LINC01173 expression was linked with fasting glucose and HbA1C alteration. Collectively, lncRNA LINC01173 expression, vitamin-D alteration, as well as smoking habit may cause the disease severity and increase the pathogenesis of disease.
Answers are grounded in this paper and cite their sources.
LINC01173 may mark T2DM with vitamin D deficiency; hypothesis-generating and requires prospective validation before clinical use.
No takes yet. Share an insight, caveat, or question.
Aladel et al. (2022) conducted a case-control in Type 2 diabetes mellitus. Type 2 diabetes mellitus vs. Healthy controls was evaluated on lncRNA LINC01173 expression (6.67-fold increase). Type 2 diabetes cases exhibited a 6.67-fold increase in lncRNA LINC01173 expression compared to healthy controls, with higher expression significantly associated with vitamin-D deficiency and smoking.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: