Key result
Interferon-alpha treatment of Daudi cells mediated a time-dependent suppression of all mitochondrially encoded mRNAs and cellular respiration, dependent on protein synthesis and transcription.
Why the study?
Does interferon treatment suppress mitochondrial mRNA levels and cellular respiration in Daudi cells?
Population
Daudi cells
Comparison
Interferon (IFN-alpha) treatment vs Untreated cells (implied)
Design
Preclinical
Authors
Loading...
No change to interferon regimens indicated; leaves open extension to in vivo mitochondrial effects.
Does interferon treatment suppress mitochondrial mRNA levels and cellular respiration in Daudi cells?
Interferon-alpha suppresses mitochondrial mRNA transcription and cellular respiration in Daudi cells, providing insight into its anticellular mechanisms.
Lou et al. (1994) studied this question. Interferon (IFN-alpha) was evaluated on Suppression of mitochondrially encoded mRNAs and cellular respiration. Interferon-alpha treatment of Daudi cells mediated a time-dependent suppression of all mitochondrially encoded mRNAs and cellular respiration, dependent on protein synthesis and transcription.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: