September 1, 1976Proceedings of the National Academy of SciencesOpen Access

Interferon-induced inhibition of protein synthesis in L-cell extracts: an ATP-dependent step in the activation of an inhibitor by double-stranded RNA.

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Population

L-cell extracts (interferon-treated and control)

Comparison

Addition of double-stranded RNA at 400 ng/ml and… vs Control cell extracts; systems without dsRNA or…

Design

Preclinical

Authors

WRWalden K. RobertsUniversity of Colorado Hospital MCM J ClemensSt George's Hospital IKIan M. KerrThe Honourable Society of Lincoln's Inn

Discussion

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Implication

Supports stepwise interferon activation in cell systems; leaves open relevance to human cardiovascular disease.

Structured PICO

Population

L-cell extracts (interferon-treated and control)

Intervention

Addition of double-stranded RNA (dsRNA) at 400 ng/ml and ATP

Comparator

Control cell extracts; systems without dsRNA or ATP

Outcome

Inhibition of translation of encephalomyocarditis virion RNAsurrogate

The study proposes a two-step model for interferon-induced inhibition of protein synthesis where a pre-inhibitor is activated by dsRNA in an ATP-dependent manner.

Cite This Study

Roberts et al. (1976) studied this question.

synapsesocial.com/papers/6a8950c610850cc06fbd4a13 https://doi.org/10.1073/pnas.73.9.3136

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Interferon-induced inhibition of protein synthesis in L-cell extracts: an ATP-dependent step in the activation of an inhibitor by double-stranded RNA.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Interferon-induced inhibition of protein synthesis in L-cell extracts: an ATP-dependent step in the activation of an inhibitor by double-stranded RNA.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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