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April 1, 1971Journal of VirologyOpen Access

Protein Synthesis in Cell-Free Systems: an Effect of Interferon

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Why the study?

Does interferon treatment inhibit viral protein synthesis at the translational level in cell-free systems?

Population

Ribosome and cell-sap fractions from chick embryo fibroblasts in mixed chick-mouse and purely chick…

Comparison

Interferon treatment of cells vs Control chick embryo fibroblasts

Design

Preclinical

Authors

IKIan M. KerrThe Honourable Society of Lincoln's Inn

Discussion

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Implication

Supports interferon-mediated translational control in cell-free systems; leaves open relevance to intact cells or clinical antiviral use.

Structured PICO

Does interferon treatment inhibit viral protein synthesis at the translational level in cell-free systems?

P
Population
Ribosome and cell-sap fractions from chick embryo fibroblasts in mixed chick-mouse and purely chick cell-free systems
I
Intervention
Interferon treatment of cells (or interferon added directly to the cell-free system)
C
Comparator
Control chick embryo fibroblasts (no interferon treatment)
O
Outcome
Synthesis of viral polypeptide(s) in response to viral ribonucleic acid (RNA) / translation activitysurrogate

Interferon treatment of chick embryo fibroblasts reduces the rate or frequency of translation of EMC virus RNA in cell-free systems, suggesting a potential mechanism for viral protein synthesis inhibition.

Limitations

  • Competition between endogenous and added messengers cannot be excluded
  • Results do not provide definitive evidence for or against the hypothesis that virus protein synthesis is inhibited at the translational level

Cite This Study

Ian M. Kerr (1971) studied this question.

synapsesocial.com/papers/6a703b75ac440176ef28e2d9https://doi.org/10.1128/jvi.7.4.448-459.1971
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1SELECTIVE TRANSLATION OF T4 TEMPLATE RNA BY RIBOSOMES FROM T4-INFECTED <i>Escherichia coli</i>1969 · 85 citations
  2. 2Studies on protein and nucleic acid metabolism in virus-infected mammalian cells. 1. Encephalomyocarditis virus in Krebs II mouse-ascites-tumour cells1961 · 124 citations
  3. 3The Effect of Interferon on the Synthesis of RNA in Chick Cells Infected with Semliki Forest Virus1967 · 43 citations
  4. 4Ribosomes: Effect of Interferon on Their Interaction with Rapidly Labeled Cellular and Viral RNA's1967 · 58 citations